Aromatase inhibitors and estrogen blockers: Nature's answer to xenoestrogens and aging

Estrogen blockers, aromatase inhibitors(AI's) and estrogen detoxifiers, offer all round approach in fighting excess estrogen.

Although estrogen is important hormone for our well being, especially for women, high amounts can cause serious health problems, in both sexes. There are three types of estrogen, estrone (E1), estradiol (E2), and estriol (E3).

However, not all of them are made equal. Estradiol is the most strongest, natural occuring estrogen which has a great influence on males too, since it is involved in testosterone feedback loop.

In men, estrogens are produced from androgens such as testosterone, by enzyme aromatase which increases with aging.


Our enviroment is filled with estrogen mimicking chemicals known as xenoestrogens which pollute the foods we eat and the water we drink.

By ingesting these chemicals, we are boosting the process of aromatization, thereby stimulating aromatase enzyme. This increases estrogen levels in the blood because of which women and men are getting more feminine.

While you may think that this is a good news for women and bad for men, you are wrong. It is bad for both sexes. However, estrogen blockers, aromatase inhibitors and estrogen detoxifiers are natural solutions for these problems.

High estrogen increases the risk of prostate problems, low libido, male breast cancer, short stature and gynecomastia, in men.

On the other hand, women these days have bigger breasts, more feminine characteristics and higher sex drive. However, because of it, women are also getting diagnosed with breast and ovarian cancer in their twenties, while experiencing weight gain and fertility problems.

Heart disease is another problem since high estrogen also affects the heart muscle and blood clotting mechanisms as well as other hormones which are crucial for normal heart function.


Estrogen is a crucial part of feedback loop of our hormonal system. Endocrine system is always trying to establish homeostasis. However, when estrogen is high, it signals the endocrine system that balance is already established which prevents further production of several hormones.

This is most apparent with testosterone but it affects other hormones which are precursors to testosterone and estrogens such as DHEA, progesterone and androstenedione.


I have tried many supplements. While couple of them have been very effective, I saw the biggest improvement with these anti-estrogen supplements, besides adaptogens, Hawthorn, vitamin D, Forskolin and fish oil.

The most potent estrogen blockers and aromatase inhibitors are:

  • Chrysin (5'7-Dihydroxyisoflavone) is a flavonoid from blue passion flower which has shown to be the most powerful natural aromatase inhibitor. However, its low bioavailability gives weak results in real life. To overcome that, you should consume it with piperine from black pepper, dihydroxybergamottin (DHB) from grapefruit or both.
  • White Button Mushrooms seems to be very powerful aromatase inhibitor with great real life results.
  • Trans-Resveratrol is not as strong as other AI's but it works. It also has numerous other health benefits, especially regarding the cardiovascular system.
  • Daidzein (4'7-Dihydroxyisoflavone) is a strong isoflavonoid extracted primarily from Kudzu root. Although it is not as strong as Chrysin, the body absorbs it much better.
  • Hesperetin is created by metabolising hesperidin in the stomach which is found in citrus fruits, especially orange.
  • Naringenin is another citrus bioflavonoid whose metabolites are able to inhibit aromatase enzyme and reduce estrogen.
  • Nettle Root contains probably the weakest of all aromatase inhibitors, 3,4-Divanillyltetrahydrofuran and Secoisolariciresinol.
  • CAPE from Bee Propolis is a natural SERM and estrogen blocker. It is one of the newest addition in the fight against xenoestrogens. It is helpful for men suffering from prostate cancer, women battling breast cancer as well as for reducing the risk of heart disease.
  • Vitamin D is another natural aromatase inhibitor. It is one of the reasons why so many teens experience growth spurt during summer.
  • Turmeric may also help, by occupying estrogen receptors. 
  • 7-MF (7-Methoxyflavone) is natural compound with powerful aromatase inhibiting properties, superior bioavailability as well as strong resistance to hepatic breakdown. Don't confuse it with methoxyISOflavone. 7-MF is completely different compound. 
  • Acacetin (4'methoxy-5,7-dihydroxyflavone) is one of natural aromatase inhibitors isolated from the damiana plant which may suppress up to 63 percent of aromatase activity. Unlike some other natural AI's, it has no estrogenic activity at all. 
  • NOTE: Although phytoestrogens such as Chrysin and Daidzein as well as natural SERMs such as CAPE, Turmeric and Resveratrol may inhibit aromatase enzyme to some degree, they are primarily estrogen blockers. They bind to estrogen receptors thereby blocking estrogen which causes an increase in testosterone, progesterone, DHEA and androstenedione.


    When we have blocked estrogen and lowered its production with aromatase inhibitors, we have to detoxify excess estrogen as well as xenoestrogens. This is where the liver comes.

    Liver is a detox powerhouse which is responsible for detoxification of our blood. When it is clogged, it can't do its job. However, there are a couple of liver herbs which can improve its function. They are:

    • Milk Thistle
    • Prunella Vulgaris
    • Artichoke
    • Dandelion
    • Burdock
    • Yellow dock
    • Adaptogens
    • Turmeric

    Besides these liver herbs, there are some supplements which have a direct effect on estrogens metabolism. They are:

  • Indole-3-Carbinol or I3C is found in cruciferous vegetables. It helps detoxify estrogens because of which it works very well with estrogen blockers.
  • Diindolylmethane or DIM is a metabolite of I3C. It is stronger and more effective compound which increases the amount of good estrogens, while reducing the amount of bad estrogens and xenoestrogens. When you take DIM, you may notice a change in your urine color. Those are the toxins and estrogens being flushed out from the body. The best time to take it, is before bed or after you wake up since hormone levels are raising at night, during sleep.
  • Ingredients: White Button Mushrooms, Acacetin, 7MF, Daidzein, DIM, Zinc, Selenium + ALA, Bioperine & Vanadyl Sulfate


    In order to lower estrogen, you don't need to take any supplements such as aromatase inhibitors. You can get them from food and sunlight.

    Just eat white button mushrooms, citrus fruits, broccoli, brussels sprouts, spice up your food with turmeric and black pepper, drink a glass of red wine per day and get a healthy dose of sunlight to increase your vitamin D levels.

    Also, the amount of fat you have is directly connected with how much estrogen you produce since fat cells contain the aromatase enzyme. Losing weight and lowering fat percentage will help lower aromatase enzyme, while detox, estrogen blockers and aromatase inhibitors will help with weight loss.

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